Anticarcinogenic activity of rosemary loaded solid lipid nanoparticle against solid tumor in mice.

Document Type : Original full papers (regular papers)

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1 قسم علم الحيوان كلية العلوم جامعة الفيوم

2 قسم علم الحيوان كلية العلوم جامعة القاهرة

3 Department of Physiology National Organization for Drug Control and Research (NODCAR), Giza, Egypt

Abstract

Abstract
 The present research conducted to evaluate the in vivo anticancer activity of rosemary extract (RSE) loaded solid lipid nanoparticles (SLNs) in a mice model bearing Ehrlich solid carcinoma (EAC). Tumor-bearing mice were haphazardly distributed to four distinct groups (6 animals / group) plus normal control group (5 total groups). Mice inoculated with EAC cells in the second group received SLNs only. In the third and fourth groups, animals received two different doses (200 and 400 mg/kg) of the formulated RSE loaded SLNs. Hematological and biochemical alterations were evaluated in all animal groups after four weeks of treatment. Mortality rate, Tumor size, Tumor Necrosis Factor-alpha (TNF-α) were estimated in addition to flow cytometery analysis. Our results indicated that animals treated with RSE loaded SLN showed a marked reduction in tumor size, mortality rate and TNF- α level as compared to EAC group. In conclusion, Rosemary loaded SLN shows promising anticancer efficacy and displayed great potential as a therapeutic agent in cancer treatment., this could serve as an initiative for developing new cancer therapeutics.

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