EUPHORBIA AMMAK LEAF EXTRACT MITIGATES HYPERGLYCEMIA IN STZ-INDUCED TYPE 2 DIABETIC MOUSE MODEL.

Document Type : Original full papers (regular papers)

Authors

1 Zoology department, Faculty of Science, Fayoum, Egypt

2 Zoology Department, Faculty of Science, Fayoum, Egypt

3 Physiology Department, Egyptian drug authority, Egypt

4 Biochemistry Department, Faculty of Medicine, Cairo University, Egypt

Abstract

Euphorbia species have been employed to treat conditions such as cancer and headaches, exhibiting pharmacological properties that include antiviral, anticancer, antimicrobial, and antifungal effects. This research evaluates the ameliorative effects of different Euphorbia ammak extract (EAE) concentrations against hyperglycemia in the streptozotocin-induced type 2 diabetic mouse model. Thirty-six male mice were randomly allocated to six groups (n=6). The experiment consisted of six experimental groups: Group 1 was the normal control; Group 2 was the diabetic control; Group 3 was diabetic mice with a low dose of EAE treatment; Group 4 was diabetic mice with a high dose of EAE treatment; Group 5 was normal mice with a low dose of EAE treatment; and Group 6 was normal mice with a high dose of EAE treatment. EAE was administered via gavage for 21 days post-STZ injection. Samples of blood are used for different biochemical tests, such as measurements of insulin levels and serum lipid profiles. Diabetic control mice showed significant increases in blood glucose, triglycerides (TGs), serum total cholesterol (TC), very-low-density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C), and decreases in high-density lipoprotein cholesterol (HDL-C). Treatment with EAE significantly reduced fasting blood glucose, TGs, serum TC, VLDL, LDL-C. Meanwhile, EAE-treated groups approached normal levels for serum insulin and HDL-C. The results indicate that EAE oral administration may have amelioratory effects against deleterious hyperglycemic and hyperlipidemic manifestations of diabetes mellitus.

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